Shopping Cart
Your Cart is Empty
There was an error with PayPalClick here to try again
CelebrateThank you for your business!You should be receiving an order confirmation from Paypal shortly.Exit Shopping Cart

Agape Healing Arts

Health & Wellness Center

385 Tequesta Drive Ste. 4 Tequesta FL 33469 ~ Office 561-762-4273



C-reactive protein (CRP)

Posted on May 28, 2020 at 11:20 PM

C-reactive protein (CRP)


The condition is low-grade inflammation, which may originate in a variety of unlikely places throughout the body, including even excess fat. New federal recommendations are being written that will urge doctors to test millions of middle-aged Americans for it.

The discovery of its surprising ill effects is causing a top-to-bottom rethinking of the origins and prevention of heart trouble. Doctors call it a revolutionary departure from viewing the world's top killer as largely a plumbing problem blamed on cholesterol-clogged arteries, the standard theory through the modern era of cardiology.

"The implications of this are enormous," says Dr. Paul Ridker of Boston's Brigham and Women's Hospital. "It means we have an entire other way of treating, targeting and preventing heart disease that was essentially missed because of our focus solely on cholesterol."

Testing Healthy People

In the past year or two, experts say, the evidence has become overwhelming that inflammation hidden deep in the body is a common trigger of heart attacks, even when clogging in the arteries is minimal. Now the main question is: How aggressively should otherwise healthy people be tested to find and treat it?

The new recommendations are still being drawn up, but they will offer the first formal blueprint to answer this, probably sometime in the fall. Doctors writing them say they will almost certainly recommend broad testing.


Inflammation can be measured with a generic $10 test that looks for high levels of a chemical called C-reactive protein, one of many that increase during inflammation. Experts expect it to quickly become a standard part of physical exams. As a result, many people ordinarily consid- ered at low risk will probably be put on statin drugs, which lower inflammation as well as cholesterol.


No one disputes the importance of cholesterol. Yet half of all heart attack victims have levels that are normal or even low. Clearly, something big was missing from the equation, and that appears to be inflammation.


Ridker estimates that between 25 million and 35 million healthy middle-aged Americans have normal cholesterol but above-average inflammation, putting them at unusual risk of heart attacks and strokes.


A series of landmark studies by his team, beginning in 1997, suggest inflammation is more important than cholesterol at triggering heart attacks. They found those with high levels of C-reactive protein have twice the risk of people with elevated cholesterol.


High amounts of the protein also predict increased risk of heart attacks and strokes years before they occur, even when cholesterol levels are low. Having both inflammation and high cholesterol together is especially ominous, resulting in a nine-fold increase in risk.


Everyone who reaches middle age has some degree of fatty buildup, called plaque, in the heart arteries. The new evidence suggests it becomes threatening if weakened by inflammation, which makes it squishy and fragile. Even a small lump of plaque can burst like an overripe pimple, prompting the formation of a clot that in turn chokes off blood flow and causes a heart attack.


Many people with no outward signs of anything wrong have high levels of internal inflammation. It is exactly the same sort that causes swelling, heat and redness during infections or allergic rashes.


Doctors believe the internal inflammation has many possible sources. Often, the plaque itself becomes inflamed as white blood cells invade in a misguided defense attempt. But inflammation that arises elsewhere apparently can be as bad, for it bombards the plaque with damaging chemicals.


For instance, fat cells churn out these inflammatory proteins, which helps explain why being overweight is so bad for the heart. Other possible triggers include high blood pressure, smoking and lingering low-level infections, such as chronic gum disease.


Although many chemicals increase during inflammation, C-reactive protein, or CRP, is particularly easy to measure. Some already test for it, including White House doctors, who checked President Bush's CRP level last summer. (His was extremely low.)

CRP Recommendations

In March, the Centers for Disease Control and Prevention and the American Heart Association held a meeting of 50 experts in Atlanta to review the scientific evidence on inflammation and make recommendations.

These are still being discussed, but some doctors involved say they are likely to urge CRP screening for people already considered at mild to moderate risk of heart attacks. These include smokers and those with a combination of other less ominous risks, such as being middle-aged and having borderline high cholesterol or blood pressure. For instance, they might recommend


CRP testing for a 45-year-old man with cholesterol in the low 200s and blood pressure just be- low the cutoff for treatment.  However, others believe CRP should measured in everyone over age 40, just like cholesterol, regardless of their other risk factors.  "It begins to look like a standard risk factor that one would evaluate at least once in middle age in most people," says Dr. Wayne Alexander of Emory University, one member of the recom- mendations committee. "This is a very important concept for the general public to be aware of and to think about for their own health."

Doctors hope to have the recommendations ready for publication in the journal Circulation in November, followed by a campaign to teach doctors and ordinary people about it. "Our goal is to have a broad-based consensus and use all available means to disseminate that information widely," says Dr. George Mensah, the CDC's chief of cardiovascular health.  Many hospitals can already do the test. However, until the recommendations come out, most doctors are unlikely to know exactly whom to test or what to make of the results. In fact, the White House doctors who checked Bush had to call Ridker to figure out how to interpret his numbers.

The Effects of CRP Screening

CRP probably will not matter much for heart attack survivors and others who already know they have heart disease, since presumably doctors are already doing everything they can to keep their condition from getting worse.

"We believe the niche for C-reactive protein - and it is a large niche - is the healthy population who want to do what they can to lower their risk of cardiovascular disease," says Dr. Richard Cannon of the National Heart, Lung and Blood Institute.

Screening is important because inflammation can be readily lowered in several ways. One of the most powerful is losing weight. Exercise also helps, as does moderate alcohol intake, giving up smoking and lowering blood pressure.

Of course, this amounts to the same healthy living advice that doctors have long dispensed. But now they have a much better understanding of why it works so well. Furthermore, they are likely to urge these habits on people with bad CRP readings who until now would have seemed to be at no special risk of heart problems.


Many of the standard heart medicines also lower inflammation. These include aspirin, Plavix, ACE inhibitors and the statin drugs, such as Lipitor and Zocor. The statins are now prescribed to lower cholesterol, and they do so dramatically. But studies have shown they ward off heart attacks much more powerfully than would be expected from their effects on cholesterol alone. In fact, people with moderate cholesterol seem to benefit just like those with readings off the charts. Lowering inflammation probably explains why.

Still, some important details remain to be settled. One is population-wide data on CRP levels and their connection to heart disease. Ridker is finishing a large study, to be released later this year, that traces this relationship with CRP readings from tens of thousands of people.

"Paul has got data now that slam-dunks it," says Dr. Richard Milani of the Ochsner Clinic in New Orleans.

Another gap is rock-solid evidence that lowering inflammation truly prevents heart attacks and saves lives. Ridker hopes to prove this with a study to begin this fall that will compare statin drugs and dummy pills in 15,000 middle-aged men and women with normal cholesterol and above average CRP.

The new thinking about inflammation "will change everything we do in heart disease," predicts Dr. Eric Topol, cardiology chief at the Cleveland Clinic.

"In the last decade, people talked about their cholesterol levels," he says. "In the next decade, the cocktail chatter will be, 'What's your C-reactive protein?' Everyone will need to know that."

Categories: None

Post a Comment


Oops, you forgot something.


The words you entered did not match the given text. Please try again.


Reply Edgarlaf
2:38 PM on July 29, 2022 
citalopram 20 mg daily
Reply air jordan
2:12 PM on July 29, 2022 
I must express my thanks to you for bailing me out of this difficulty. Just after looking throughout the the net and meeting thoughts which were not beneficial, I was thinking my life was well over. Living without the presence of answers to the problems you have fixed all through your entire article is a crucial case, and those which may have in a negative way affected my career if I hadn't encountered your web site. Your own personal ability and kindness in dealing with every aspect was valuable. I'm not sure what I would have done if I hadn't come across such a thing like this. I'm able to now look ahead to my future. Thanks a lot so much for this impressive and results-oriented guide. I won't hesitate to refer the website to any person who would need assistance about this situation.
air jordan
Reply Terryles
1:41 PM on July 29, 2022 
The Vault offers a multitude of strains high in quality for its growers. If you are in the US, you can expect your seeds to arrive in five to eight days. New office buildings are designed to cater to this change in trends, and landlords are seeking to retrofit existing buildings with new entry lobbies, increased capacity in the end of trip facilities and on floor services that are commensurate with new buildings however, this is not always possible.
Reply cheap giannis shoes
12:13 PM on July 29, 2022 
I wish to express my love for your kind-heartedness supporting those people who absolutely need help with your topic. Your very own dedication to passing the solution across became exceptionally productive and has consistently encouraged folks like me to arrive at their desired goals. The valuable information implies a whole lot to me and further more to my colleagues. Regards; from all of us.
cheap giannis shoes
Reply kd 12
12:12 PM on July 29, 2022 
Thanks for all your valuable hard work on this web page. My daughter loves setting aside time for investigation and it's obvious why. A number of us hear all about the powerful way you deliver valuable tips and tricks by means of your web site and therefore cause participation from the others about this theme plus our own child is actually studying a whole lot. Enjoy the rest of the year. You are carrying out a stunning job.
kd 12
Reply golden goose outlet
12:11 PM on July 29, 2022 
I wish to show thanks to you just for bailing me out of such a situation. After checking throughout the online world and meeting thoughts which were not pleasant, I assumed my life was over. Existing without the strategies to the issues you've fixed all through your good article is a critical case, as well as those that might have in a wrong way damaged my entire career if I had not encountered your web site. Your main talents and kindness in touching almost everything was helpful. I'm not sure what I would have done if I hadn't come upon such a stuff like this. I'm able to now relish my future. Thanks a lot so much for this impressive and effective guide. I won't hesitate to endorse your web blog to any individual who ought to have care about this topic.
golden goose outlet
Reply golden goose sneakers
12:10 PM on July 29, 2022 
Thanks a lot for providing individuals with remarkably superb opportunity to read in detail from this website. It is always so brilliant and stuffed with fun for me and my office mates to search the blog really thrice every week to see the fresh secrets you will have. And indeed, I'm also at all times amazed considering the mind-blowing concepts you give. Selected two areas in this post are particularly the most suitable I have had.
golden goose sneakers
Reply kobe byrant shoes
12:10 PM on July 29, 2022 
I intended to post you the very little remark in order to thank you so much yet again over the pleasant techniques you've featured in this case. This is simply surprisingly generous with you giving freely exactly what numerous people could have marketed as an ebook to earn some cash for themselves, primarily seeing that you might have tried it in the event you considered necessary. The good tips likewise worked to be the good way to be certain that someone else have a similar dreams similar to my personal own to grasp very much more in respect of this issue. I am certain there are lots of more pleasurable periods in the future for people who looked at your website.
kobe byrant shoes
Reply cheap kd 12
12:09 PM on July 29, 2022 
My husband and i felt really fortunate Emmanuel could do his basic research through the entire precious recommendations he came across through your web page. It's not at all simplistic to just always be giving away points that some people might have been trying to sell. And we also fully grasp we now have you to give thanks to for this. These explanations you made, the simple site navigation, the friendships your site make it easier to instill - it is all amazing, and it's really helping our son and us believe that that issue is thrilling, which is highly fundamental. Many thanks for all!
cheap kd 12
Reply bape hoodie
12:08 PM on July 29, 2022 
I want to show appreciation to you just for bailing me out of this type of challenge. Because of surfing around throughout the online world and obtaining proposals which were not helpful, I assumed my life was done. Being alive devoid of the approaches to the problems you've resolved by way of this posting is a critical case, as well as the kind that might have adversely damaged my career if I had not noticed your web blog. Your primary know-how and kindness in handling a lot of stuff was priceless. I don't know what I would have done if I had not come across such a step like this. I can also at this point look ahead to my future. Thank you so much for this expert and sensible help. I will not be reluctant to refer your web sites to anybody who ought to have tips on this topic.
bape hoodie
Reply cheap kobe bryant shoes
10:03 AM on July 29, 2022 
My spouse and i were now satisfied when Albert could carry out his survey through your ideas he grabbed through the weblog. It is now and again perplexing to simply always be freely giving tips and hints that other folks have been selling. So we know we need the writer to be grateful to for that. The specific explanations you made, the straightforward blog navigation, the relationships you help to create - it is most powerful, and it's really assisting our son in addition to the family recognize that that theme is awesome, and that is particularly fundamental. Thanks for the whole lot!
cheap kobe bryant shoes
Reply golden goose
10:03 AM on July 29, 2022 
I want to convey my passion for your kindness in support of people who really want assistance with in this study. Your real dedication to getting the message throughout has been pretty good and has regularly enabled regular people much like me to reach their dreams. Your entire warm and friendly publication denotes this much a person like me and extremely more to my office workers. Thank you; from all of us.
golden goose
Reply cheap kd shoes
10:03 AM on July 29, 2022 
My spouse and i ended up being absolutely fulfilled that Jordan managed to do his research through your precious recommendations he gained using your web page. It's not at all simplistic just to happen to be releasing tips and tricks which the others might have been making money from. And we grasp we have the website owner to be grateful to because of that. Most of the illustrations you made, the easy website menu, the relationships you will aid to engender - it's got everything fantastic, and it's leading our son in addition to the family consider that that content is thrilling, and that's really vital. Many thanks for all the pieces!
cheap kd shoes
Reply bape hoodie
10:03 AM on July 29, 2022 
I enjoy you because of your whole effort on this site. Gloria really loves going through research and it is simple to grasp why. Most of us hear all regarding the compelling form you render advantageous thoughts by means of the blog and in addition recommend contribution from the others on the subject matter while our own princess is certainly being taught a great deal. Have fun with the remaining portion of the year. You have been carrying out a really great job.
bape hoodie
Reply off white outlet
10:00 AM on July 29, 2022 
A lot of thanks for your entire work on this web page. Debby take interest in going through internet research and it's simple to grasp why. Most of us learn all of the dynamic tactic you present effective things through this web blog and even recommend response from some others on this area of interest so our girl is actually being taught a lot. Take advantage of the rest of the new year. You are always conducting a dazzling job.
off white outlet
Reply pg 4
10:00 AM on July 29, 2022 
I not to mention my buddies came analyzing the excellent key points located on your site and so instantly got an awful suspicion I had not expressed respect to you for them. Most of the young men came as a consequence passionate to read them and have in effect undoubtedly been tapping into those things. Thank you for turning out to be really kind and also for having certain fabulous ideas millions of individuals are really needing to be informed on. My sincere regret for not expressing appreciation to you earlier.
pg 4
Reply Jacklat
8:45 AM on July 29, 2022 
Reply RalphCap
8:01 AM on July 29, 2022 
???????? ????? ?????? ???? ???????????? ???? ?????? ????? ? ????????

????? ?????? ??????? ???? ???????? ?????????
?????? ????? ???? ?????? ??? ???
????? ???????? ?????? ????????
???????? ????? ?????? ??????? ???
??????? ????? ?????? ?? ??????? ?????
???? ????? ?????? ??????? ?? ??????? ?????????
????? ???????? ?????? ?? ?????? ???????
????? ?????? ??????? ?????? ????
????? ???????? ?????? ????
????? ?????? ??????? ??????? ???? ?????????
Reply chrome hearts online
4:52 AM on July 29, 2022 
Thank you a lot for providing individuals with a very memorable opportunity to read articles and blog posts from this website. It is often very sweet and packed with a great time for me personally and my office acquaintances to visit your blog at the very least thrice in a week to study the fresh things you will have. And indeed, I'm also actually satisfied for the beautiful techniques served by you. Some 1 tips on this page are indeed the most efficient we have all ever had.
chrome hearts online
Reply golden goose
2:32 AM on July 29, 2022 
My husband and i felt now thrilled Peter managed to deal with his inquiry from the precious recommendations he came across from your blog. It is now and again perplexing to just choose to be offering procedures other folks might have been selling. And we all do understand we need the writer to be grateful to for that. The main illustrations you made, the straightforward blog menu, the friendships you will give support to foster - it's got everything extraordinary, and it is making our son in addition to our family consider that the article is amusing, and that's truly vital. Thank you for everything!
golden goose